Which non-antimicrobial strategy is significant in decreasing the risk of postoperative infection?

Maintaining normothermia is a significant non-antimicrobial strategy in decreasing the risk of postoperative infection because it helps in stabilizing the patient's immune response and minimizes the risk of wound complications. Hypothermia can lead to a decrease in immune function, increased metabolic activity, and impaired wound healing, all of which can contribute to a higher risk of infection. By carefully managing a patient's temperature during and after surgery, healthcare providers can play a crucial role in enhancing recovery and reducing infection rates.

In contrast, while antibiotic prophylaxis and optimal skin antisepsis are indeed effective strategies for infection prevention, they fall under the category of antimicrobial approaches. The focus of the question is specifically on non-antimicrobial strategies, which makes the emphasis on maintaining normothermia particularly relevant for reducing postoperative infection risks.