What is a potential concern when using Ketamine in large doses?

When using Ketamine in large doses, a significant concern is the potential for hallucinations and respiratory depression. Ketamine is a dissociative anesthetic, meaning it can cause a disconnection between sensory inputs and the perception of them. High doses can lead to altered mental states, including vivid hallucinations, which can be distressing for the patient.

Respiratory depression is another critical concern with increased doses of Ketamine. While it is known for its safety margin in anesthetic settings, larger doses can suppress respiratory drive, leading to inadequate ventilation and oxygenation. This dual effect—of causing both altered perceptions and risks to respiratory function—highlights the importance of careful dosing and monitoring when using this medication, especially in non-overseen settings.

While other options present valid concerns in different contexts or doses, the combination of hallucinations and respiratory depression is particularly acute at higher doses, which is why it is essential to consider these effects when administering Ketamine in a clinical environment.